Background: Dental caries is the most common microbial disease affecting mankind. Caries risk assessment\nmethods, identification of biomarkers and vaccine development strategies are being emphasized to control the\nincidence of the largely preventable disease. Pattern recognition receptors such as the toll like receptors (TLR) have\nbeen implicated as modulators of host-microbial interactions. Soluble TLR-2 and its co-receptor, CD14 identified in\nsaliva can bind the cell wall components of cariogenic bacteria and modulate the disease process. The objective of\nthis study is to determine the potential of salivary sTLR-2 and sCD14 as biomarkers of caries activity and indirect\nmeasures of the cariogenic bacterial burden.\nMethods: Unstimulated whole saliva was collected from twenty caries free and twenty caries active children\nbetween the ages of 5 and 13 years. The concentration of sCD14 and sTLR-2 together with that of the cytokine IL-8\nreported to be increased in dental caries was assessed by the enzyme linked immunosorbent assay.\nResults: While the level of sCD14 and that of IL-8 was equivocal between the two groups, the sTLR-2 concentration\nin caries active saliva was significantly higher than that in caries free saliva.\nConclusions: The sTLR-2 in saliva could serve as a potential biomarker for caries activity.
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